SEROLOGY OF SYPHILIS BASED ON RECENT OBSERVATIONS*t
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Physicians and serologists have faced a number of questions associated with sero-diagnostic reactions in syphilis which have been difficult to answer. For example, it may be asked how is it possible for serum reactions employing lipid antigens, apparently unrelated to the Treponema pallidum, to behave as though they were specifically associated with syphilis, as shown by the remarkable parallelism between serologic and clinical findings in this disease ? Also, how can the same serum reactions behave as though they were totally unrelated to syphilis, as shown by the instances of biologic false positives noted in such a wide variety of non-syphilitic conditions ? These two basic questions, as well as some others, are answerable according to recent observations mnade in this laboratory. As a first step it is necessary to recognize that the serology of syphilis is not a field complete in itself but a branch of a more comprehensive field of serology with lipid antigen. Some 30 years ago when we reported a test for :syphilis based on precipitation (Kahn, 1923), we ibelieved that the reaction between serum and lipid antigen was limited to syphilis; that any reactions obtained in the absence of syphilis were due commonly to technical error or perhaps to some deficiency of sero-diagnostic tests; that the very nearly perfect test would be free from false positives. More recently it was reported from this laboratory (Kahn, 1947) that the same lipid antigens (Kolmer, cardiolipin, Kahn) which generally give specific
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SEROLOGY OF SYPHILIS BASED ON RECENT OBSERVATIONS*t
Physicians and serologists have faced a number of questions associated with sero-diagnostic reactions in syphilis which have been difficult to answer. For example, it may be asked how is it possible for serum reactions employing lipid antigens, apparently unrelated to the Treponema pallidum, to behave as though they were specifically associated with syphilis, as shown by the remarkable parallel...
متن کاملDevelopment of a real-time PCR assay to detect Treponema pallidum in clinical specimens and assessment of the assay's performance by comparison with serological testing.
The incidence of infectious syphilis in men who have sex with men and human immunodeficiency virus-infected patients has increased steadily in Victoria, Australia, since 2002. A TaqMan real-time PCR assay targeting the polA gene of Treponema pallidum (TpPCR) was developed. The analytical sensitivity of the assay was estimated to be 1.75 target copies per reaction. Initially, the assay was used ...
متن کاملNotification and management of congenital syphilis in the Northern Territory 2009 to 2014.
OBJECTIVE To determine whether cases of congenital syphilis in the Northern Territory between 2009 and 2014 were correctly notified based on probable or confirmed case criteria stipulated by the Communicable Diseases Network Australia (CDNA). METHODS Pregnant women with positive syphilis serology defined as reactive treponemal test and rapid plasma reagin titre ≥1:8 were identified from the N...
متن کاملBiological false reactive VDRL tests: when to re-test?
Syphilis serology is a basic screening test for the workers who want to go abroad. Many countries reject migrant workers who have reactive syphilis serology. Biological false reactives warrant repeated syphilis serology. We prospectively studied 30 patients (25 males and 5 females) who had biological false reactive VDRL tests (VDRL reactive, confirmatory TPHA negative). Affirmative tests for sy...
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تاریخ انتشار 2004